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A study has shown that UDCA, as an FXR inhibitor, can directly inhibit the gene expression and replication of HBV and reduce the accumulation of toxic bile acids (such as taurocholic acid)

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Thus, several epigenetic regulatory networks have been investigated in cardiovascular diseases with the introduction of sequencing technology (122), and the three main epigenetic mechanisms constitute of DNA methylation, histone modification and the involvement of non-coding RNA (123)