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Vitamin B12 Why it matters: Found naturally in animal foods, vitamin B12 regulates key metabolic processes in the body both directly and as a cofactor (or "helper molecule") for two enzymes (methionine synthase and L-methylmalonyl-coenzyme A mutase)

Pros Can be very sensitive due to filling if complexity is low Can be very robust Can work quickly Cons Has poor performance compared to other systems such as quadrupoles Can have low sensitivity if you are looking at low abundance ions in a background of high abundance ions these will limit the fill of the trap before selection Ion fragmentation Collision cell Overview This technology is well established and the most common method of fragmentation

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The obesity trial ran 46 weeks with roughly 60% completion, and the MASH trial ran 48 weeks