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This review demonstrated that compared with placebo interventions, probiotics, and other non-pharmacological treatments, acupuncture had a larger therapeutic effect on stool frequency, response rate, and had a lower rate of adverse events, providing some reasonable convincing evidence on acupuncture relatively ranked the best in managing CFC

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Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial