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Both of the double blinded randomised intervention trials provided information about concealment and the laboratory was blinded thereby reducing performance and detection bias [64, 65]

Thus, targeting of the transporters expressed only at the BBB would be useful in terms of delivery of drugs with extracellular targets in the brain, while utilization of the transporters expressed at the BBB and cellular membrane of the brain parenchymal cells is essential for delivery of the drugs with intracellular targets