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Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator

Similar to Nrf2, the protective effect of heme oxygenase-1 (HMOX-1, or HO-1) in normal cells may protect from oxidative stress-related diseases

The E-cadherinMerlinHippoYAP axis has been shown to control ACSL4 transcription, thereby linking cellcell contact signaling to ferroptosis susceptibility [93], and further supporting ACSL4 as a pivotal mediator of ferroptotic regulation [94]

Experimental models demonstrate that AOD 9604 modulates lipolysis through 3-adrenergic receptormediated pathways, which are central to triglyceride breakdown in adipocytes