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In melanoma and breast cancer mouse models, it has been observed that mice fed a low-protein diet (4% kcal protein) exhibit reduced IGF-1 levels and slower tumor progression compared to those fed a high-protein diet (18% kcal protein)

Acknowledgements This work was supported by a project (HI21C0694, Development of treatment for intractable skin diseases using low-molecular compounds with enhanced Wnt/beta-catenin) funded by the Ministry of Health and Welfare, Republic of Korea and by the National Research Foundation of Korea(KRF) grant funded by the Korea government(MSIT) (RS-2025-16072747)