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Trseid, M

Macrophages play a pivotal role in the inflammatory process, and upon activation by LPS, they generate significant quantities of pro-inflammatory cytokines

Immunohistochemistry Five tissue microarrays slides of the 122 cases of malignant peripheral nerve sheath tumor, WTS slides of the 40 cases of malignant peripheral nerve sheath tumor (matched with those in tissue microarrays of malignant peripheral nerve sheath tumor), WTS slides of the 28 cases of primary desmoplastic/spindle cell melanomas, tissue microarrays slides of the 8 cases of primary melanomas and tissue microarrays slides of 229 cases of metastatic melanomas were deparaffinized in xylene, hydrated in alcohol, and baked in a microwave (30 min in Tris-buffer, pH 9)

Plasma protein expression in FM has been correlated with pain severity, with an upregulation of proteins involved in immune and inflammatory processes, including upregulation of ceruloplasmin, a key acute-phase reactant (Ghafouri et al., 2023)