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Astrocytic 2 -adrenergic receptors mediate hippocampal long-term memory consolidation

Such reduction in SIRT1 activity explains why the levels of acetylated forms of PGC-1, NF-B p65, p53, and Nrf2 were significantly increased in the livers of APAP-treated rats which may explain the concomitant lower levels of antioxidants, higher Bax/Bcl-2 ratio, and increased NF-B activity and inflammatory cytokine levels

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