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32 Moreover, aging is closely associated with oxidative stress, and aged mice showed reduction of stress tolerance, lower GSH/GSSG ratio and higher MDA levels in the liver compared with young mice

However, the inner gate is substantially reconfigured in the shift from the inward-facing open states to the CtAtm1 inw-opn-occl conformation, reorienting the N395 and F396 pairs, first pointing toward and away from the cavity, respectively, and then vice versa (Fig