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J Appl Physiol 113:10513

Hyperinsulinemia resulting from insulin resistance can itself stimulate inflammatory pathways

Cell-mediated immunity primarily needs protein antigen degradation in the endocytic vesicles of antigen presenting cells (macrophages, dendritic cells), to be able to present smaller peptides on the cell surface through major histocompatibility complex antigens to activate antigen-specific T cell proliferation