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Interestingly, as in the FAD mouse model, lysosomal TRPML1 activation, by inducing autophagy, also promotes autophagy stress and the focal axonal swellings filled with autophagic vacuoles, which are associated with coding variants of PLD3 that increase AD risk 142,143

[9] Nursing mothers excrete a relatively low and non-toxic concentration of INH in breast milk, and their babies are at low risk for side effects

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