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Description

They are different expressions of the same upstream dysfunction in different people

Recent developments in HA research underscore its tunable, molecular weightdependent bioactivities, wherein high-molecular-weight HA (HMW-HA) exerts anti-inflammatory and tissue-protective effects, while low-molecular-weight HA (LMW-HA) fragments promote angiogenesis and fibroblast activation

Additionally, inhibiting Ang II has a positive impact on endothelial function in patients with hypertension and MetS [173], and patients with hypertension-associated ED can benefit from the treatment with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers [174]