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Reduced Inflammation The peptide helps people with diseases like arthritis and sports injuries by reducing inflammation and pain

10.1371/journal.pgen.1011723 181 VenediktovA

Considering that ESM1 increases the binding of VEGF to VEGFR2 (46), and PI3K/AKT/mTOR is downstream of the VEGF/VEGFR2 pathway (54), this suggests that ESM1 activates the PI3K/AKT/mTOR pathway via the phosphorylation of VEGFR2, consequently upregulating the aforementioned angiogenesis-related factors