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The impact varies significantly: Impact on Executive Functions Executive functions play a crucial role in daily activities

(Basel) 9 , 897 (2020)

The FOXO1 (5DUI) was found to have hydrophobic, hydrogen, and polar amino acid interactions with SER 184, GLN 185, GLU 188, LYS 192, and LYS 233

Pregnancy: There are no data from the use of pemetrexed in pregnant women but pemetrexed, like other antimetabolites, is suspected to cause serious birth defects when administered during pregnancy,so should not be used during pregnancy unless clearly necessary, after a careful consideration of the needs of the mother and the risk for the foetus