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Evidence has not consistently shown sublingual B12 to be superior to high-dose oral tablets

But this category is another example where the claims are outpacing the actual evidence

(2023) loaded the hydrophobic core of amphiphilic polycarbonate cationic nanoparticles with the nerve growth factor receptor antagonist TrkA-IN-1 and incorporated the drug-loaded nanoparticles into a decellularized annulus fibrosus matrix (DAF) hydrogel, which could inhibit the formation of a chronic inflammatory microenvironment by pro-inflammatory factors and nerve growth factor-induced nerve ingrowth into the annulus fibrosus

The Cleveland Clinic recommends aggressive hydration for patients on GLP-1 agonists