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TIGHT JUNCTION STRUCTURE OVERVIEW The intestinal epithelial monolayer serves as both an innate immune barrier to restrict translocation of potentially harmful luminal contents, including microorganisms, toxins, and foreign antigens, as well as acting as a selective filter to allow for proper absorption of nutrients, water, and electrolytes into the circulation (9)

However, systemic effects from distant-site injection are also documented, and for diffuse neuropathies affecting multiple nerve territories, systemic administration may provide more uniform coverage

MAla analyzed genomic data