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The similar protective effect of a miR-19a-3p inhibitor, resulting in a reduced infarct volume, better neurological outcomes together with enhanced cell viability and decreased inflammation, was reversed by IGFBP-3 silencing, suggesting that IGFBP-3 is anti-apoptotic in this model [95]

Schymeinsky J, Then C, Sindrilaru A, Gerstl R, Jakus Z, Tybulewicz VL, Scharffetter-Kochanek K, Walzog B

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The research shows that IGF-1 treatment in the elderly can preserve lean muscle mass [3]