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Tirzepatide is a first-in-class dual incretin receptor agonist a single molecule that activates both the GIP (glucose-dependent insulinotropic polypeptide) and the GLP-1 (glucagon-like peptide-1) receptors, which is why it is often nicknamed a twincretin. [7] By engaging two incretin pathways it enhances glucose-dependent insulin secretion, promotes satiety, and delays gastric emptying, producing large effects on both glycemic control and bodyweight

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Of all the TRAF members, TRAF2 is expressed most abundantly and has been subjected to intense research

An intravaginal live Candida challenge in humans leads to new hypotheses for the immunopathogenesis of vulvovaginal candidiasis