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The basic structure and function of the glycocalyx have been thoroughly studied, but some of the mechanisms involved have not been fully elucidated (25)

When dehydrated, they are more prone to fatigue and tension, contributing to discomfort and pain

These alterations in the tumor ECM induce an increase in its stiffness, typically evaluated using techniques that either require direct contact with the sample (e.g., atomic force microscopy), or measure the tumor mechanical properties in a contact-free manner (e.g., shear wave elastography, magnetic resonance elastography) (Table 3)

If you suspect you've experienced a side effect from either medication, report it through the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)