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These are consistent with the mechanism of action slowing gastric emptying affects digestion, and central appetite suppression can cause nausea, particularly during the early stages of treatment and dose escalation

According to the National Institutes of Health (NIH), no Tolerable Upper Intake Level (UL) has been established for B12, indicating that the risk of harm from high doses is low [*]

Kirk FT, Munk DE, Swenson ES, Quicquaro AM, Vendelbo MH, Larsen A

This data strengthened the clinical profile of NPWT and supported payer coverage, illustrating how RCTs can complement regulatory clearance with robust evidence