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Disruption of mitochondrial dynamics may serve as an early event in the neurodegenerative process, leading to synaptic dysfunction and neuronal network impairment

Experimental models have examined their potential involvement in appetite-related signaling, energy balance pathways, and autonomic nervous system interactions

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Patient Warnings: Patients taking selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, or other drugs that affect serotonin levels should avoid taking 5-HTP without the supervision of a physician due to the theoretical potential for serotonin syndrome, a serious condition, or other side effects