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GoyalMMenonBKVan ZwamWHDippelDWJMitchellPJDemchukAMet al

We have also shown that ductal cells found within isolated primary human islets exhibit a similar transcriptional signature as PANC-1 cells, particularly a strong transcriptional signature associated with type I IFNs, which may contribute to the cytokine storm preceding disease onset (116, 149)

Recent studies have shown that obesity mediates dysfunction in human adipose-derived MSCs through epigenetic alterations in 5-hydroxymethylcytosine (5hmC), particularly affecting genes involved in mitochondrial function