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Anti-CD38 antibodies mediate anti-myeloma activity through multiple mechanisms of action both in patients with RRMM and with newly diagnosed MM, although immunomodulatory effects may be greater in earlier disease settings in which the immune system has not been affected by prior treatments [85]

The recommended dose is: At the start of treatment, 1 ml (1 ampoule) is administered once or twice a week in the first two weeks after diagnosis, corresponding to 1000 - 2000 g cyanocobalamin per week

*J Orthop Res.* 28(9):1155-1161

While animal and early human studies indicate possible roles in adipose regulation, the compound remains under investigation across several scientific fields