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Apo- and mesohemerabbit HPX (90%) or proto-hemehuman HPX complexes (33.9 mM and 38.3 mM, respectively) were investigated

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Mitochondrial reactive oxygen species release is unaltered by IF In addition to determining changes in functional parameters, we measured the release of mitochondrial H 2 O 2 , a relatively stable and membrane-permeable ROS often used as a marker for oxidant production (Fig

17 Under hypoxic conditions, a decrease in hydroxylation results in a reduction in the synthesis of the VHL and HIF-1 complex, which in turn promotes the stable production of HIF-1