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In contrast, at more mature synapses, the calcium nanodomains defined by calcium influx via only NMDARs and VGCCs seem to be sufficient for bAP-induced site-specific local BDNF release from dendrites

However, other observations suggest that the residual CD38 low/- NK population displays a high proliferative potential and functional activity

We report the development and validation of cell-based platform assays for a class of incretin molecules

395 The loss of double-strand repair pathway due to BRCA1 or BRCA2 mutations renders cancer cells more dependent on the PARPs-mediated repair, and more sensitive to PARP inhibition, raising a possibility of a wider application of PARPi in cancer therapy