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Anti-CD38 monotherapy studies which consists of only multiple myeloma patients were excluded from analysis since CD38 acts directly on the myeloma cells and not within the scope of this study ( Supplementary Figure 6

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As described previously, CD38 inhibits the proliferation of memory CD4 + and CD8 + T cells via the alternative ectoenzymatic pathways that produce ADOresponsible for its suppression [51]