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However, the downside to most collagen products is that the collagen peptide molecule tends to be too large to absorb efficiently into the skin, which means it will deliver subtle effects compared to copper peptides

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"Greenspan's Basic & Clinical Endocrinology 10th Edition" Journal of Applied Physiology

[2] An important caveat applies to all of this work: these studies measure DSIP-like immunoreactivity (DSIP-LI) using antisera, which detects material that cross-reacts with the antibody