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The average dosage is calculated as 2.2375 mcg/day (PDF)

Keller S, Ruetz M, Kunze C, Krutler B, Diekert G, Schubert T

Similarly, some patients may have digestive issues that prevent them from absorbing enough B12 from their food

This makes it uniquely effective for: Visceral fat reduction (glucagon is specifically active on abdominal fat stores) Resting metabolic rate increase (glucagon is thermogenic it raises your metabolic baseline) Food noise suppression (GLP-1 component dampens reward-driven eating) Satiety signaling (GIP + GLP-1 extend fullness after meals) Because of this third mechanism, the clinical trial results for Retatrutide are notably better than other approved GLP-1s for body weight reduction