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Cancer-associated adipocytes exhibit phenotypic changes including secretion of the lipids, inflammatory cytokines, and an imbalance in adipokine signaling pathways, such as the upregulation of leptin and downregulation of adiponectin, which promote tumor proliferation and invasion (123)

Hydropersulfides are thought to mediate many of the antioxidant signaling functions once ascribed purely to hydrogen sulfide via modification of protein cysteine (Cys) residues in a process referred to as persulfidation

Published preclinical studies used intraperitoneal injection in rodents, which bypasses the subcutaneous absorption variability human protocols face