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Despite Addisons early findings, it wasnt until 1871 when a more accurate description was made, this time by Michael Biermer, a German physician, who wrote about a disorder he called progressive pernicious anaemia or as he would have said progressiver, perniciser anaemie

By changing these habits, people can lower their deficiency risk

Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)