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[DOI] [PMC free article] [PubMed] [Google Scholar] 1235.Galimberti S, et al

CB1, the primary cannabinoid receptor in the nervous system, is one of the most abundantly expressed GPCRs in the CNS and is predominantly found in neurons (Hoffman et al., 2021)

Together, these shortcomings prevent natural products from reaching the affected brain regions in concentrations sufficient to exert meaningful therapeutic effects 88,89