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RMT involves three key steps: (1) therapeutic molecules or ligands designed to mimic endogenous substrates bind to specific receptors expressed on the luminal (blood-facing) surface of the ECs

That study revealed that ferrylHb but not Hb or metHb induce active IL-1 production in LPS-primed macrophages in an NLRP3-dependent manner ( Hemorrhage-Associated Macrophage Subsets Besides the two extreme canonical macrophage phenotypes, the pro-inflammatory M1 and the anti-inflammatory M2, many other specific and distinct macrophage subsets exist (103)

Botulinum toxin injections are also a treatment for blepharospasm

Think of it as increasing the number of factories, not just making the existing ones bigger