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Trimnell et al, 2005)

Similar trends were observed at the protein level: JSH-23 pretreatment prevented H 2 O 2 -induced marked reductions in Runx2, OCN and BMP2 levels (Figures 6D,E)

doi:10.1021/acs.chemrev.5b00484 42

This binding prevents misfolding and aggregation of procollagen and facilitates its transport to the Golgi apparatus ( Clinical and preclinical evidence supports a critical role for HSP47 in fibrogenesis