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The discoid lateral meniscus is one of the most common abnormal meniscal variants in children, estimated to have an incidence of 1 to 3% in the pediatric population (Kushare, Klingele, and Samora 2015

For example, some studies have found that the secondary mutations of D1228N/V and Y1230C in the MET kinase domain are the main mechanisms for acquired resistance to crizotinib in METex14 patients receiving c-MET inhibitor treatment [149, 150]