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Cyanocobalamin, the second form, is the most common form of B12 provided at physician offices and in over-the-counter supplements

doi: 10.1038/s41587-019-0036-z 28 TucciPPortelaMChettoCRGonzalez-SapienzaGMarinM

These measures counterbalance the mild stimulatory effect

In a double blind, placebo-controlled, phase III study, benfotiamine was effective in lowering the neuropathy symptom score, even though total symptom score was not changed after treatment