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Trends Immunol (2016) 37:193207

butyrate enemas may have a role as an adjunct in treatment-refractory distal UC but replacing mesalazine or steroids with butyrate enemas for established disease is not evidence-based Assuming oral sodium butyrate supplementation at standard supplement doses (150-600 mg/day) delivers meaningful colonic concentrations: standard oral butyrate supplement doses are absorbed almost entirely in the small intestine and do not provide meaningful distal colonic delivery

Smith-Lemli-Opitz syndrome (SLOS) is an autosomal disorder associated with cholesterol biosynthesis

This is often due to a poor diet and less stomach acid, which the body needs to absorb B12 from food