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PBS was used as a negative control, while urokinase (3 mg/mL) was used as a positive control

PLoS One 15 , e0240106 (2020)

Microarray analysis of human pulmonary endothelial cells revealed the upregulation of 245 genes, including those encoding growth factors, cytokines, receptors, signal transduction molecules, and transcription factors, as commonly elevated genes in response to both HIF-1 overexpression and hypoxic incubation 22