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Pain as an Integral Component of Wound Pathophysiology Regardless of the underlying cause, every wound is associated with varying degrees of pain, defined as an unpleasant sensory and emotional experience associated with, or pretending to be associated with, actual or potential tissue damage [30]

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It was previously documented that M2 polarisation is attributed to many factors, such as decreased activation of ERK, mitigated liberation of ROS and suppressed NF-B-p65 expression (Su et al

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