Microbiome Dysbiosis and the Gut Epithelial Barrier in Colorectal Cancer Development Recent compelling evidence in both animal models and human studies suggest that infections by bacterial pathogens, commensal microbial dysregulation, and resultant alterations in microbial products are involved in CRC development ( The gut barrier is a dynamic and complex environment and acts as a physical and chemical barrier that suppresses the access of pathobionts, antigens and other invasive bacteria into the host ( Although the definition is not well established and the composition of the microbiome varies among individuals ( Bacteroides and Firmicutes represent a major part of the bacteria in the gut while phyla such as Proteobacteria, Verrucomicrobia, Actinobacteria , Cyanobacteria and Fusobacteria are present in lower abundance ( VDR gene, encoding the vitamin D receptor ( NOD2, LCT and MUC2 genes, implicated in the regulation of immune response and secretion of anti-bacterial compounds ( Bifidobacterium abundance ( FUT2 , a gene regulating the expression of histo-blood group antigens on the gastrointestinal mucosa ( MyD88 , TLR4 and TLR5 , have been associated with changes in the microbiome composition ( Several research groups have evaluated microbiome components as CRC screening biomarkers, employing qPCR of extracted DNA from either stool, including secondary use of stool based diagnostic tests (e.g., FIT), or tumour tissue samples, to associate the relative abundance of bacterial species with colorectal lesions
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doi: 10.1016/S2666-5247(24)00055-7 34 PelusoMJRyderDFlavellRRWangYLeviJLaFranchiBHet al
