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A Phase 2 study published in The New England Journal of Medicine (Jastreboff et al., 2023) reported substantial weight reduction in participants with obesity

Gloves (optional) for maintaining sterility

Other authors suggested that gliadin was able to bind the mono-sialic ganglioside 1 (GM1) or the receptors for the proinflammatory chemokine 3 (CXCR3) in mouse models, leading to the release of zonulin which in turn decreases electrical resistance of epithelial layers, finally resulting in increased epithelial permeability (139, 255)

In extreme or severe cases, you might consider a gut reset with the elemental diet