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Effect of pulmonary damage on the pharmacokinetics of inhaled therapeutics In this section, we review how damaged respiratory tissue and disrupted pulmonary mechanisms affect the pharmacokinetics of inhaled drugs, notably, discussing the effects upon absorption, distribution, metabolism and elimination of prevalent medications such as beta agonists and inhaled corticosteroids

Electroporation Electroporation employs high-voltage electric pulses (typically ranging from 100 to 1000 V) of short duration (microseconds to milliseconds) to temporarily permeabilize cell membranes or the skin

Understanding physiological and molecular defense strategies adopted by both hyperaccumulator and non-hyperaccumulator plants to cope with metal stress either during accumulation, degradation or elimination of metal pollutants in contaminated soils are of the utmost significance in phytoremediation studies

We derived this estimate by dividing the observed effect sizes of significantly differentially methylated CpG sites in our dataset (0.020.07 for 8/9 CpG sites) by the estimated group exposure contrast (the difference in median total hair mercury was 12.40.48 = 11.92 g/g), which yielded slopes ranging from (0.02/11.92 =) 0.002 to (0.07/11.92 =) 0.006