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NNMT is an enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (MNA) and S-adenosylhomocysteine (SAH)

MAPK, Mitogen-activated protein kinase

Since attaining approval by the Chinese Food and Drug Administration in 2011, icotinib, marketed under the brand name Conmana, has reported to have over a third of the Chinese market share in lung cancer therapies.[1] The US patent application for the preparation of icotinib and icotinib hydrochloride was filed on December 28, 2012 and the patent was granted on July 21, 2015.[2] There are currently no active or recruiting clinical trials for icotinib in the United States.[3] Currently, icotinib is the only marketed drug product from Betta Pharmaceuticals, primarily accounting for the companys $1.289 billion earnings in sales in 2016.[4] Beta Pharma owns the international development and production rights of icotinib outside of China

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