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Pulse corticosteroid therapy with oral dexamethasone for the treatment of adult alopecia totalis and universalis

Kidney Int (2021) S0085-2538(21):003781

It highlights the pathological processes through which gut microbiota dysbiosis exacerbates systemic inflammation and lung injury via multiple pathways, including alterations in metabolites (such as bile acids and tryptophan), inhibition of the anti-inflammatory pathway mediated by the vagus nerve, and activation of TLR signals in the lungs by circulating toxins

We highlight immune, metabolic, and neural routes, with emphasis on converging evidence from experimental and clinical studies