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There were no published randomized controlled trials (RCT) with Se as the only intervention agent

Finally, tyrosine residues were also found to be halogenated by HOCl and HOBr, yielding 3-chlorotyrosine (with a second-order rate constant k = 47 M 1 s 1 [178]) and 3-bromotyrosine, respectively

For instance, synthetic drugs are often derived from chemical reagents or scarce natural products dependent on non-renewable resources, whereas live bacterial drugs are predominantly sourced from readily available, biodegradable natural material [14, 15]

Over the past few decades, various diagnostic frameworks have been established, with the most widely adopted being the 1990 National Institutes of Health (NIH) criteria, the 2003 Rotterdam Consensus, and the 2006 Androgen Excess and PCOS Society (AES) criteria