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doi:10.1002/jor.21107 Japjec M, Pavlov KH, Petrovic A, et al

Older adults Reduced stomach acid and intrinsic factor production make absorption more difficult with age

Over time, this can contribute to a worsening overall skin condition

A Phase 2 trial (NCT01311518) was designed to test RGN-352 in ~75 heart attack patients, but was placed on FDA clinical hold in 2011 due to manufacturing (GMP) compliance issues at the contract site not safety concerns with the drug itself