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Together, these findings show that disease-associated loss of ACSM3 facilitates mitochondrial dysfunction via a lauric acid-HNF4a-p38 MAPK axis, suggesting a novel therapeutic vulnerability in systemic metabolic dysfunction

Classically, the efficacy and usage of carrier- and bioprecursor-type prodrugs have long been established

Most bacteria in the human gut are not pathogenic or parasitic but commensal. Their population density is largest by far in the large intestine, or colon