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For additional information regarding the policy finalized for CY 2025, reference 89 FR 93948 through 93963

These limitations have spurred growing interest in alternative interventions, notably intermittent fasting (IF), a dietary regimen characterized by alternating periods of fasting and eating 5,6,7

This contrasts with observations from various other tissues and cells exposed to high glucose levels in vitro, typically within the 20 mM to 30 mM range, where chronic exposure (e.g., in podocytes, endothelial cells, myotubes, epithelial cells, pancreatic cells, and aortic tissues) often resulted in basal respiration rates that either remained unchanged or were reduced (Audzeyenka et al

Mller endfeet contribute to the neurogliovascular unit that maintains the blood-retina barrier (Figure 16, control) and also secrete the basement membrane forming the inner limiting membrane through which the retina interacts with IOP