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10.1016/j.cub.2014.07.034 37 DaiW.XuY.MoS.LiQ.YuJ.WangR.et al (2020)

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neurodegeneration can stimulate further inflammatory activity, resulting in further neuronal damage and death

However, it has been shown that TET-mediated DNA oxidation induced by vitamin C can create a synthetic lethality, where AML cells being forced to undergo active DNA demethylation renders them hypersensitive to PARP inhibition ( Conclusion Given the numerous roles for vitamin C in biological processes that maintain and influence genomic stability, it is no surprise that vitamin C continues to be explored for potential anticancer activity