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Low glutathione levels can increase oxidative stress, inflammation, and gut permeability (leaky gut)

Analysis of labeled BCAAs metabolites showed more labeled -Ketoisocaproate (-KIC) and Leu-derived BCKAs in NSCLC cells

Our analysis revealed a surprising overlap between proteins downregulated upon BSO treatment and mitochondrial GSH depletion, suggesting that most of the proteomic changes that occur upon cellular GSH depletion are likely due to mitochondrial effects (Fig