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Those with higher ergothioneine levels showed: 50% reduced risk of cognitive decline over five years Better memory performance across all age groups Brain activity patterns more similar to younger individuals on cognitive tasks Professor Barry Halliwell, one of the worlds leading experts on antioxidants at the National University of Singapore, explained the mechanism: Ergothioneine gets into mitochondria and preserves mitochondrial function in disease

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Bioorg Chem 85:128139 Bayrak , Uc EM, Rezaei M, Gulin , Menzek A (2022) Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products